Search results for "RETROSPECTIVE STUDY"

showing 10 items of 34 documents

Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients

2016

Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different et…

Male0301 basic medicinePediatricsAdult-onset Still's diseaseSettore MED/16 - REUMATOLOGIALeukocytosisClinical presentationArthritisComorbidityDiseaseLaboratory finding0302 clinical medicineAdrenal Cortex HormonesLeukocytosisAdult-onset Still’s diseaseBiologic drugsMedicine (all)General MedicineMiddle AgedRashRetrospective studyTreatment OutcomeItalyAdult-onset Still’s disease; Biologic drugs; Clinical presentation; Laboratory findings; Retrospective study; Rheumatology; Medicine (all)Antirheumatic AgentsFemalemedicine.symptomStill's Disease Adult-OnsetAdultLaboratory findingsmedicine.medical_specialtyAdolescentFeverNOYoung Adult03 medical and health sciencesRheumatologyInternal medicinemedicineHumansAgedRetrospective Studies030203 arthritis & rheumatologybusiness.industryAdult-onset Still’s disease; Biologic drugs; Clinical presentation; Laboratory findings; Retrospective study; RheumatologyRetrospective cohort studymedicine.diseaseNeutrophiliaRheumatologySurgery030104 developmental biologybusinessBiologic drug
researchProduct

The Congenital Hypothyroidism Screening Programme in a Sigle Italian Centre: A 5-Years Retrospective Study

2018

Congenital hypothyroidism (CH) occurs in approximately 1:2,000-1:3,000 newborns in Italy. Lowering of the TSH cut-off was the most important factor contributing to the increase of CH incidence in Italy. The aim of this study is the determination of the prevalence of CH in northwest Sicily, evaluated by the single screening centre of the Children Hospital “G. Di Cristina”, ARNAS, Palermo. From January 2013 to December 2017, 79.699 newborns were screened testing TSH from blood spots. The neonates with TSH≥6mU/L were recalled measuring serum fT4, fT3, TSH, anti- TG and anti-TG antibodies, and thyroid echography. To evaluate the effect in lowering the TSH cut-off, we compared the cases of confi…

Congenital Hypothyroidism Screening Retrospective Study
researchProduct

A retrospective follow up study on maternal age and infant mortality in two Sicilian districts

2011

Abstract Background Infant mortality rate (IMR) is a key public health indicator. Maternal age is a well-known determinant of pregnancy and delivery complications and of infant morbidity and mortality. In Italy the Infant Mortality Rate was 3.7/1000 during 2005, lower than the average IMR for the European Union (4.94/1000). Sicily is the Italian region with the highest IMR, 5/1000, and neonatal mortality rate (NMR), 3.8/1000, with substantial variation among its nine districts. The present study compared a high IMR/NMR district (Messina) with a low IMR/NMR district (Palermo) during the period 2004-2006 to evaluate potential determinants of the IMRs' differences between the two districts and…

AdultMalePediatricsmedicine.medical_specialtyretrospective studySettore MED/42 - Igiene Generale E Applicatasymbols.namesakeEpidemiologyInfant Mortalitymedicinemedia_common.cataloged_instanceHumansAdvanced maternal agePoisson regressioninfant mortality rateRegistriesEuropean unionSicilymedia_commonRetrospective StudiesPregnancybusiness.industrylcsh:Public aspects of medicinePublic healthPublic Health Environmental and Occupational HealthInfant NewbornInfantlcsh:RA1-1270medicine.diseaseInfant mortalitysymbolsFemaleLive birthbusinessDemographyResearch ArticleFollow-Up StudiesMaternal AgeBMC Public Health
researchProduct

A maChine and deep Learning Approach to predict pulmoNary hyperteNsIon in newbornS with congenital diaphragmatic Hernia (CLANNISH): Protocol for a re…

2021

Introduction Outcome predictions of patients with congenital diaphragmatic hernia (CDH) still have some limitations in the prenatal estimate of postnatal pulmonary hypertension (PH). We propose applying Machine Learning (ML), and Deep Learning (DL) approaches to fetuses and newborns with CDH to develop forecasting models in prenatal epoch, based on the integrated analysis of clinical data, to provide neonatal PH as the first outcome and, possibly: favorable response to fetal endoscopic tracheal occlusion (FETO), need for Extracorporeal Membrane Oxygenation (ECMO), survival to ECMO, and death. Moreover, we plan to produce a (semi)automatic fetus lung segmentation system in Magnetic Resonanc…

Pediatricsmedicine.medical_treatmentretrospective studyDiagnostic RadiologyCohort StudiesStudy ProtocolMathematical and Statistical TechniquesPregnancyMedicine and Health SciencesLung volumesMultidisciplinarymedicine.diagnostic_testRadiology and ImagingStatisticsQRSoftware EngineeringMagnetic Resonance ImagingPulmonary Imagingmachine learningObstetric ProceduresPhysical SciencesEngineering and TechnologyMedicineFemaleCohort studyComputer and Information Sciencesmedicine.medical_specialtyImaging TechniquesHypertension PulmonaryScienceSurgical and Invasive Medical ProceduresResearch and Analysis MethodsPulmonary hypertensionComputer SoftwareDiagnostic MedicineArtificial IntelligenceCongenital Diaphragmatic Hernia Pulmonary Ipertension Deep Learning protocolmedicineExtracorporeal membrane oxygenationHumansHerniaStatistical MethodsRetrospective StudiesFetal surgerybusiness.industrydiaphragmatic herniasegmentationInfant NewbornBiology and Life SciencesNeonatesCongenital diaphragmatic herniadeep learningRetrospective cohort studyMagnetic resonance imagingmedicine.diseaseSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Hernias Diaphragmatic CongenitalbusinessMathematicsDevelopmental BiologyForecasting
researchProduct

Palliative sedation in advanced cancer patients followed at home: A retrospective analysis

2012

Abstract CONTEXT: Data regarding palliative sedation at home in dying patients are lacking. OBJECTIVES: To describe the frequency, indication, and modality of palliative sedation (PS) in patients followed at home. METHODS: A retrospective analysis of home care cancer patients was performed. Patients who received PS before dying were selected and information about epidemiologic characteristics, indications, duration, drugs, and outcomes was collected. RESULTS: Of 370 medical charts of patients who died at home, 49 patients received PS before dying. PS was proposed by the team, relatives, or both in 63.3%, 4.1%, and 32.6% of cases, respectively. Delirium alone or in combination with other sym…

end of lifeMalePediatricsmedicine.medical_specialtyPalliative carePainComorbiditySettore MED/42 - Igiene Generale E ApplicataPalliative sedationadvanced cancer patientPalliative sedationRisk FactorsNeoplasmsRETROSPECTIVE STUDYPrevalenceMedicineHumansHypnotics and SedativesPALLIATIVE SEDATION; advanced cancer patients; RETROSPECTIVE STUDYIntensive care medicineSurvival rateGeneral NursingSurvival analysisNursing (all)2901 Nursing (miscellaneous)Retrospective StudiesTerminal Carepalliative carebusiness.industryDeliriumRetrospective cohort studymedicine.diseaseComorbidityHome Care ServicesSurvival AnalysisSurvival RateTreatment OutcomeAnesthesiology and Pain MedicineItalyend of life; home care; palliative care; Palliative sedation; Comorbidity; Delirium; Female; Home Care Services; Humans; Hypnotics and Sedatives; Italy; Male; Neoplasms; Pain; Palliative Care; Prevalence; Retrospective Studies; Risk Factors; Survival Analysis; Survival Rate; Terminal Care; Treatment Outcome; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)MidazolamDeliriumFemaleNeurology (clinical)medicine.symptombusinesshome caremedicine.drug
researchProduct

Yellow (577 nm) micropulse laser versus half-dose verteporfin photodynamic therapy in eyes with chronic central serous chorioretinopathy: results of …

2018

PurposeTo compare the functional and anatomical outcomes of eyes with chronic central serous chorioretinopathy treated with yellow micropulse (MP) laser versus half-dose verteporfin photodynamic therapy (PDT).MethodsThis is a multicentre, retrospective comparative study of 92 eyes treated with yellow MP laser (duty cycle of 5%, zero spacing between spots, spot size varied from 100 to 200 µm, power varied from 320 to 660 mW, and the pulse burst duration was 200 ms) and 67 eyes treated with PDT (half-dose verteporfin (3 mg/m2) infused over 10 min), followed by laser activation for 83 s. Spot sizes varied from 400 to 2000 µm.ResultsIn the MP group, at 12 months of follow-up, the mean best corr…

Laser surgeryMaleFluorescein angiographyretinaVisual acuityoptical coherencegenetic structuresPhysiologymedicine.medical_treatmentCentral serous chorioretinopathyVisual AcuityPhotodynamic therapytreatment lasersProceduresPhotodynamic therapychemistry.chemical_compound0302 clinical medicineBest corrected visual acuityMedicineFluorescein AngiographyTreatment outcomeMiddle agedTomographyPriority journalLow level laser therapyPhotosensitizing Agentsmedicine.diagnostic_testMiddle AgedFluorescein angiographyVerteporfinPhotosensitizing agentsSensory SystemsIndocyanine greenMulticenter studyBevacizumabClinical trialRetrospective studyTreatment OutcomeCentral Serous ChorioretinopathyFemaleLaser Therapymedicine.symptomTomography Optical Coherencemedicine.drugHumanIndocyanine GreenAdultmedicine.medical_specialtyVisual acuityLaser surgeryMajor clinical studyFollow-up studiesPathophysiologyArticleChronic disease03 medical and health sciencesCellular and Molecular NeuroscienceLaser therapyOphthalmologyFluorescence angiographyHumansmaculaLow level laser therapyRetrospective StudiesDisease durationPhotosensitizing agentOptical coherence tomographybusiness.industryIntermethod comparisonSubretinal neovascularizationCentral serous retinopathyVerteporfinFollow upmedicine.diseaseMulticenter study (topic)eye diseasesRetrospective studiesOphthalmologyCentral serous retinopathychemistryPhotochemotherapyChronic Disease030221 ophthalmology & optometryYellow micropulse laserComparative studysense organsbusinessIndocyanine greenControlled study030217 neurology & neurosurgeryFollow-Up Studies
researchProduct

Etiological heterogeneity and clinical variability in newborns with esophageal atresia

2018

Abstract Background The aim of this study was to define different characteristics of infants with esophageal atresia and correlations with neonatal level of care, morbidity and mortality occurring during hospital stay. Methods Charts of all newborns with esophageal atresia (EA) admitted to our University NICU between January 2003 and November 2016 were reviewed and subdivided in four groups related to different clinical presentations; EA as an isolated form (A), with a concomitant single malformation (B), as VACTERL association (C), and in the context of a syndrome or an entity of multiple congenital anomalies (D). Results We recruited 67 infants with EA (with or without tracheoesophageal f…

MalePediatricsDatabases FactualAnal CanalTracheoesophageal fistulaKidneyCohort StudiesVACTERL association0302 clinical medicineMedicine030212 general & internal medicineHospital Mortalitylcsh:RJ1-570General MedicinePrognosisVACTERL associationTracheaRetrospective studyFemaleNeonatal intensive careRetrospective study Esophageal atresia VACTERL association Neonatal intensive care NewbornHeart Defects Congenitalmedicine.medical_specialtyLimb Deformities CongenitalContext (language use)Gestational AgeRisk Assessment03 medical and health sciencesEsophagus030225 pediatricsIntensive careIntensive Care Units NeonatalHumansAbnormalities MultipleGenetic Predisposition to DiseaseRetrospective Studiesbusiness.industryResearchInfant NewbornRetrospective cohort studylcsh:PediatricsLength of Staymedicine.diseaseNewbornSurvival AnalysisSpineParenteral nutritionAtresiaEsophageal atresiaEtiologybusiness
researchProduct

Opioid switching in patients with advanced cancer followed at home. A retrospective analysis.

2013

Abstract CONTEXT: Opioid switching has been found to improve opioid responsiveness in different conditions. However, data on opioid switching performed at home are almost nonexistent, despite the fact that most patients are followed at home. OBJECTIVES: The aim of this retrospective survey was to determine frequency, indications, usefulness, and safety of opioid switching when treating advanced cancer-related pain in patients followed at home. METHODS: A retrospective review of data from patients with advanced cancer followed at home by three home care teams for a period of two years was performed. Patients who had their opioids switched were selected. Reasons for switching opioid doses and…

Maleretrospective studyComorbiditySettore MED/42 - Igiene Generale E Applicataadvanced cancer patientNeoplasmsRetrospective analysisPrevalenceOpioid switching; advanced cancer patients; retrospective studyCancer painProspective cohort studyNursing (all)2901 Nursing (miscellaneous)General NursingAnalgesicsDrug SubstitutionHome Care ServicesAnalgesics OpioidCausalitySurvival RateTreatment OutcomeItalyFemaleDrugmedicine.drugmedicine.medical_specialtyAnalgesicPainContext (language use)OpioidDose-Response RelationshipmedicineHumansIn patientIntensive care medicineAgedRetrospective StudiesDose-Response Relationship Drugbusiness.industryAdvanced cancerSurvival AnalysisCancer pain; home care; opioid switching; Aged; Analgesics Opioid; Causality; Comorbidity; Dose-Response Relationship Drug; Drug Substitution; Female; Home Care Services; Humans; Italy; Male; Neoplasms; Pain; Prevalence; Quality of Life; Retrospective Studies; Survival Analysis; Survival Rate; Treatment Outcome; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)Anesthesiology and Pain MedicineOpioidEmergency medicineMorphineOpioid switchingQuality of LifeNeurology (clinical)home carebusinessJournal of pain and symptom management
researchProduct

Recognizable neonatal clinical features of aplasia cutis congenita

2020

Abstract Background Aplasia cutis congenita (ACC), classified in nine groups, is likely to be underreported, since milder isolated lesions in wellbeing newborns could often be undetected, and solitary lesions in the context of polymalformative syndromes could not always be reported. Regardless of form and cause, therapeutic options have in common the aim to restore the deficient mechanical and immunological cutaneous protection and to limit the risk of fluid leakage or rupture of the exposed organs. We aimed to review our institutional prevalence, comorbidities, treatment and outcome of newborns with ACC. Methods We conducted a retrospective study including all newborns affected by ACC and …

Male0301 basic medicinePediatricsmedicine.medical_specialtyMeningomyeloceleAbdominal compartment syndromeContext (language use)030105 genetics & heredityAplasia cutis congenita03 medical and health sciencesEctodermal DysplasiaPrevalenceHumansMedicineBody Weights and MeasuresRetrospective StudiesPregnancybusiness.industryResearchAbdominal wall defectInfant Newbornlcsh:RJ1-570Gestational agelcsh:PediatricsRetrospective cohort studyPrognosismedicine.diseaseSurvival RateAbdominal wall defectRetrospective study030104 developmental biologyItalyScalp defectFemaleApgar scoreJunctional epidermolysis bullosamedicine.symptombusiness
researchProduct

Clinical and genetic approach in the characterization of newborns with anorectal malformation

2022

Objective: This study aimed to investigate clinical, surgical, and genetic data of neonates with anorectal malformation (ARM). Study design: A retrospective observational study was conducted on neonates with ARM as an isolated type (group 1), with ≤2 (group 2), and with ≥3 associated malformations (group 3), born between 2009 and 2020. Distribution of ARM, associated abnormalities and genetic testing were analyzed, and risk factors for adverse outcomes were identified. Results: The 45 ARM cases (36% females) were divided as follows: 13 neonates belonging to group 1 (29%), 8 to group 2 (18%), and 24 to group 3 (53%). Cases were equally distributed over 11 years. Krickenbeck anatomy was: with…

MalePediatricsmedicine.medical_specialtyAnal CanalKidneymedicinecongenital abnormalitieHumansCopy-number variationimperforate anuHypertelorismbusiness.industryInfant Newborncopy number variationObstetrics and GynecologyGenetic dataRetrospective cohort studyToesmedicine.diseaseVACTERL associationhumanitiesAnorectal Malformationsbody regionsRetrospective studyUrogenital AbnormalitiesPediatrics Perinatology and Child HealthFemaleSyndactylybusinessImperforate anusVACTERL association.
researchProduct